[HTML][HTML] Extracting, filtering and simulating cellular barcodes using CellBarcode tools

W Sun, M Perkins, M Huyghe, MM Faraldo… - Nature Computational …, 2024 - nature.com
Identifying true DNA cellular barcodes among polymerase chain reaction and sequencing
errors is challenging. Current tools are restricted in the diversity of barcode types supported …

Hematopoietic Stem Cell Fates and the Cellular Hierarchy of Mammalian Hematopoiesis: from Transplantation Models to New Insights from in Situ Analyses

D Shaban, N Najm, L Droin, A Nijnik - Stem Cell Reviews and Reports, 2024 - Springer
Hematopoiesis is the process that generates the cells of the blood and immune system from
hematopoietic stem and progenitor cells (HSPCs) and represents the system with the most …

[HTML][HTML] Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

M Scherer, I Singh, M Braun, C Szu-Tu, M Kardorff… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Current approaches to lineage tracing of stem cell clones require genetic engineering or rely
on sparse somatic DNA variants, which are difficult to capture at single-cell resolution. Here …

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

S Iwanami, T Sato, H Haeno, L Xu, K Imamura… - bioRxiv, 2024 - biorxiv.org
Precise understanding how hematopoietic stem cells (HSCs) differentiate in vivo is difficult
because we can not trace the in vivo differentiation of HSCs. The single-cell transplantation …

CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanisms

V Rondeau, M Kalogeraki, L Roland, ZA Nader… - bioRxiv, 2023 - biorxiv.org
How cell-extrinsic niche-related and cell-intrinsic cues drive lineage specification of
hematopoietic multipotent progenitors (MPPs) in the bone marrow (BM) is partly understood …

Analyze lineage commitment during human hematopoiesis using somatic mitochondrial mutations

D Ginneken - 2023 - studenttheses.uu.nl
Lineage tracing is a crucial method to provide insights into the evolving landscape of
progenitor potential during lineage commitment in human hematopoiesis. A deeper …