The acquisition of genomic instability is one of the key characteristics of the cancer cell, and
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …

The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

Background Microsatellite-stable metastatic colorectal cancer is typically unresponsive to
immunotherapy. This phase 3 study was designed to assess atezolizumab plus cobimetinib …

Background This study aimed to assess the safety and tolerability of the immune checkpoint
inhibitor nivolumab, as monotherapy or combined with chemotherapy, in Japanese patients …

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-
established therapeutic target in breast and gastric cancers. Using functional and genomic …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Patients with locally advanced colorectal cancer (LACRC) have a high risk of recurrence
and metastasis, although neoadjuvant therapy may provide some benefit. However, patients …

BACKGROUND In contrast to lung cancer, few precision treatments are available for
colorectal cancer (CRC). One rapidly emerging treatment target in CRC is ERBB2 (human …

Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and
stability. Here, we investigated the characteristics of SETD2 somatic mutation in the cancer …