microRNA strand selection: Unwinding the rules
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
Regulation of microRNA biogenesis
M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
Genetic variation in microRNA networks: the implications for cancer research
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …
how their deregulation can lead to cancer. More recently, it has been proposed that the …
IsomiRs–the overlooked repertoire in the dynamic microRNAome
CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
Genome‐wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis
MicroRNAs (miRNAs) are studied as key regulators of gene expression involved in different
diseases. Several single nucleotide polymorphisms (SNPs) in miRNA genes or target sites …
diseases. Several single nucleotide polymorphisms (SNPs) in miRNA genes or target sites …
Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse …
While several studies have focused on the relationship between individual miRNA loci or
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
Common variants on 9q22. 33 and 14q13. 3 predispose to thyroid cancer in European populations
J Gudmundsson, P Sulem, DF Gudbjartsson… - Nature …, 2009 - nature.com
In order to search for sequence variants conferring risk of thyroid cancer we conducted a
genome-wide association study in 192 and 37,196 Icelandic cases and controls …
genome-wide association study in 192 and 37,196 Icelandic cases and controls …
A step-by-step microRNA guide to cancer development and metastasis
GS Markopoulos, E Roupakia, M Tokamani… - Cellular Oncology, 2017 - Springer
Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …
MicroRNAs in immune response and macrophage polarization
Inflammation is essential to combat invading microbial pathogens. In this process, the
involvement of multiple immune cell populations is crucial in mounting an optimum immune …
involvement of multiple immune cell populations is crucial in mounting an optimum immune …
Micromarkers: miRNAs in cancer diagnosis and prognosis
Molecular diagnostics in cancer should provide the highest specificity and sensitivity in
classification, prognostic stratification and early detection. miRNAs could contribute to hitting …
classification, prognostic stratification and early detection. miRNAs could contribute to hitting …