Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently,
photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however …

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

Extensive research efforts have been made and are still ongoing in the search for an ideal
anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug …

In women, breast cancer is the most common cancer diagnosis and second most common
cause of cancer death. More than half of breast cancer patients will develop metastases to …

Malignant tumors are characterized by structural and molecular peculiarities providing a
possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and …

Glioblastoma (GBM) is the most common primary brain tumor and carries a grave prognosis.
Despite years of research investigating potentially new therapies for GBM, the median …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …