Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

The pathophysiology of epilepsy has been historically grounded on hyperexcitability
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are
required for cognitive functions and disrupted in Alzheimer's disease (AD). Network …

Medial ganglionic eminence (MGE)-like interneuron precursors derived from human
induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

Current treatment options for epilepsy are inadequate, as too many patients suffer from
uncontrolled seizures and from negative side effects of treatment. In addition to these clinical …

Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most
frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the …

Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …

There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …