Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Inflammation is considered to be one of the most critical factors involved in the development
of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease …

Macrophages are widely distributed in various tissues and organs. They not only participate
in the regulation of innate and adaptive immune response, but also play an important role in …

Reactive oxygen species (ROS) play a critical role in the progression of mitochondria-
related diseases. A novel insulin sensitizer drug candidate, BGP-15, has been shown to …

Cyclophilins (Cyps) are a subgroup of peptidyl-prolyl cis-trans isomerases (PPIases) that
contain a highly conserved domain of PPIases. Sixteen Cyps have been identified in …

Drastic macrophages activation triggered by exogenous infection or endogenous stresses is
thought to be implicated in the pathogenesis of various inflammatory diseases. Carnosic …

Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a
potential role in bioenergetics is not understood. Here, we show that loss or depletion of …

Cyclophilins (Cyps) is a kind of ubiquitous protein family in organisms, which has biological
functions such as promoting intracellular protein folding and participating in the pathological …

Introduction: Cyclophilins are a family of diverse regulatory enzymes that have been studied
for over 30 years; they participate in many pathophysiological processes. Genetic deletion or …