Biomolecules adopt a dynamic ensemble of conformations, each with the potential to
interact with binding partners or perform the chemical reactions required for a multitude of …

The mechanical heterogeneity of biomolecular structures is intimately linked to their diverse
biological functions. Applying rigidity theory to biomolecules identifies this heterogeneous …

Proteins must move between different conformations of their native ensemble to perform
their functions. Crystal structures obtained from high-resolution X-ray diffraction data reflect …

Small-angle X-ray scattering (SAXS) is an increasingly common and useful technique for
structural characterization of molecules in solution. A SAXS experiment determines the …

Nucleic acids do not fold into a single conformation, and dynamic ensembles are needed to
describe their propensities to cycle between different conformations when performing …

Helix–junction–helix (HJH) motifs are flexible building blocks of RNA architecture that help
define the orientation and dynamics of helical domains. They are also frequently involved in …

Protein-RNA complexes provide a wide range of essential functions in the cell. Their atomic
experimental structure solving, despite essential to the understanding of these functions, is …

Proteins operate and interact with partners by dynamically exchanging between functional
substates of a conformational ensemble on a rugged free energy landscape. Understanding …

Ribonucleic acid (RNA) molecules are known to undergo conformational changes in
response to various environmental stimuli including temperature, pH, and ligands. In …

Cellular processes involve large numbers of RNA molecules. The functions of these RNA
molecules and their binding to molecular machines are highly dependent on their 3D …