The treatment of Cushing's disease

R Pivonello, M De Leo, A Cozzolino… - Endocrine …, 2015 - academic.oup.com
Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Glucose metabolism abnormalities in Cushing syndrome: from molecular basis to clinical management

C Scaroni, M Zilio, M Foti, M Boscaro - Endocrine reviews, 2017 - academic.oup.com
An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …

The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease

K Hayashi, N Inoshita, K Kawaguchi… - European Journal of …, 2016 - academic.oup.com
Context Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently
detected in one-to two-third (s) of corticotroph adenomas of Cushing's disease (CD). These …

Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease

M Fleseriu, R Pivonello, J Young, AH Hamrahian… - Pituitary, 2016 - Springer
Purpose In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase
inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with …

MRI–Negative Cushing's Disease: A Review on Therapeutic Management

M Sabahi, T Shahbazi, SF Maroufi, K Vidal… - World Neurosurgery, 2022 - Elsevier
Objectives In this systematic review and meta-analysis, we review the literature regarding
patients with Cushing's disease (CD) with negative or inconclusive magnetic resonance …

Болезнь Иценко-Кушинга: клиника, диагностика, дифференциальная диагностика, методы лечения

ГА Мельниченко, ИИ Дедов, ЖЕ Белая… - Проблемы …, 2015 - cyberleninka.ru
Болезнь Иценко-Кушинга: клиника, диагностика, дифференциальная диагностика, методы
лечения – тема научной статьи по клинической медицине читайте бесплатно текст …

Эндокринология

ФМ Абдулхабирова, АЮ Абросимов… - 2016 - elibrary.ru
Настоящее издание-дополненная и существенно переработанная версия клинических
рекомендаций, опубликованных в предыдущие годы, содержит информацию о …

Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) guidelines on the treatment of hyperglycemia in Cushing's syndrome and …

MG Baroni, F Giorgino, V Pezzino, C Scaroni… - Nutrition, Metabolism …, 2016 - Elsevier
Background Hyperglycemia is a common feature associated with states of increased growth
hormone secretion and glucocorticoid levels. Aims The purpose of these guidelines is to …

Effectiveness of medical treatment of cushing's disease: a systematic review and meta-analysis

J Simoes Correa Galendi, ANS Correa Neto… - Frontiers in …, 2021 - frontiersin.org
Objective The objective of this systematic review was to evaluate the effectiveness and
safety of pasireotide, cabergoline, ketoconazole, levoketoconazole, metyrapone …

The role of isotretinoin therapy for Cushing's disease: results of a prospective study

L Vilar, JL Albuquerque, R Lyra… - International Journal …, 2016 - Wiley Online Library
Objective. This prospective open trial aimed to evaluate the efficacy and safety of isotretinoin
(13‐cis‐retinoic acid) in patients with Cushing's disease (CD). Methods. Sixteen patients …