Two-dimensional liquid chromatography: a state of the art tutorial

DR Stoll, PW Carr - Analytical chemistry, 2017 - ACS Publications
In this tutorial, we discuss the motivations for doing two-dimensional liquid chromatography
(2D-LC) and describe the commonly used implementations of the method. We review …

Sampling and analysis in flow: the keys to smarter, more controllable, and sustainable fine‐chemical manufacturing

MA Morin, W Zhang, D Mallik… - Angewandte Chemie, 2021 - Wiley Online Library
Process analytical technology (PAT) is a system designed to help chemists better
understand and control manufacturing processes. PAT systems operate through the …

Comprehensive two-dimensional liquid chromatography

L Mondello, P Dugo, P Donato, M Herrero… - Nature Reviews …, 2023 - nature.com
Despite progress in hardware and column technology, the complexity and heterogeneity of
many samples still pose a challenge for state-of-the-art 1D liquid chromatography (LC). As …

Multi-dimensional liquid chromatography in proteomics—a review

X Zhang, A Fang, CP Riley, M Wang, FE Regnier… - Analytica chimica …, 2010 - Elsevier
Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

Multidimensional chromatography in food analysis

M Herrero, E Ibanez, A Cifuentes, J Bernal - Journal of Chromatography A, 2009 - Elsevier
In this work, the main developments and applications of multidimensional chromatographic
techniques in food analysis are reviewed. Different aspects related to the existing couplings …

Mass spectrometry detection in comprehensive liquid chromatography: basic concepts, instrumental aspects, applications and trends

P Donato, F Cacciola, PQ Tranchida… - Mass spectrometry …, 2012 - Wiley Online Library
The review, as can be deduced from the title, focuses on both theoretical and practical
aspects of the use of mass spectrometry as a third, added dimension to a comprehensive LC …

Comprehensive two‐dimensional liquid chromatographic analysis of rooibos (Aspalathus linearis) phenolics

T Beelders, KM Kalili, E Joubert… - Journal of separation …, 2012 - Wiley Online Library
Rooibos tea is an unique beverage prepared from unfermented and fermented plant
material of the endemic C ape fynbos plant, A spalathus linearis. The well‐known health …

Multidimensional chromatography coupled to mass spectrometry in analysing complex proteomics samples

P Horvatovich, B Hoekman… - Journal of separation …, 2010 - Wiley Online Library
Multidimensional chromatography coupled to mass spectrometry (LCn‐MS) provides more
separation power and an extended measured dynamic concentration range to analyse …

A detailed evaluation of the advantages and limitations of online RP-LCŨHILIC compared to HILICŨRP-LC for phenolic analysis

M Muller, A de Villiers - Journal of Chromatography A, 2023 - Elsevier
The combination of hydrophilic interaction chromatography (HILIC) and reversed-phase
liquid chromatography (RP-LC) has proved effective in the LC Ũ LC analysis of polyphenols …

Theories to support method development in comprehensive two‐dimensional liquid chromatography–A review

F Bedani, PJ Schoenmakers… - Journal of separation …, 2012 - Wiley Online Library
On‐line comprehensive two‐dimensional liquid chromatography techniques promise to
resolve samples that current one‐dimensional liquid chromatography methods cannot …