Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Animal models have proven to be invaluable to researchers trying to answer questions
regarding the mechanisms of behavior. The Open Field Maze is one of the most commonly …

ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

Selective macroautophagy is an important protective mechanism against diverse cellular
stresses. In contrast to the well-characterized starvation-induced autophagy, the regulation …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …