Histology and immunohistochemistry of thin tissue sections have been the standard
diagnostic procedure in many diseases for decades. This method is highly specific for …

Tissue clearing methods enable the imaging of biological specimens without sectioning.
However, reliable and scalable analysis of large imaging datasets in three dimensions …

1416-Pos Modulation of Human Stem Cell Derived Neuron Activity through Addition of an
External Conductance using Dynamic Clamp Brian K. Panama1, Leigh Korbel1, Brandon …

To quantitatively evaluate brain tissue and its corresponding function, knowledge of the 3D
cellular distribution is essential. The gold standard to obtain this information is histology, a …

Organismal phenotypes frequently involve multiple organ systems. Histology is a powerful
way to detect cellular and tissue phenotypes, but is largely descriptive and subjective. To …

Upscaling X-ray nanoimaging to macroscopic specimens has the potential for providing
insights across multiple length scales, but its feasibility has long been an open question. By …

Synchrotron-based X-ray tomography offers the potential for rapid large-scale
reconstructions of the interiors of materials and biological tissue at fine resolution. However …

We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in
neuropathologically healthy and Alzheimer's disease (AD) individuals, based on phase …

Despite advances in imaging, image-based vascular systems biology has remained
challenging because blood vessel data are often available only from a single modality or at …

Background: Micrometer-resolution neuroimaging with gold-standard conventional histology
requires tissue fixation and embedding. The exchange of solvents for the creation of …