Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …

The G1 cell-cycle kinase CDK6 has long been thought of as a redundant homolog of CDK4.
Although the two kinases have very similar roles in cell-cycle progression, it has recently …

Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …

An unresolved question is how HIV‐1 achieves efficient replication in terminally
differentiated macrophages despite the restriction factor SAMHD 1. We reveal inducible …

The high cost of drug development and the narrow spectrum of coverage typically provided
by direct-acting antivirals limit the scalability of this antiviral approach. This review …

SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase that
contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes …

SAMHD1 limits HIV-1 infection in non-dividing myeloid cells by decreasing intracellular
dNTP pools. HIV-1 restriction by SAMHD1 in these cells likely prevents activation of antiviral …