Studies performed in the liver in the 1960s led to the identification of lysosomes and the
discovery of autophagy, the process by which intracellular proteins and organelles are …

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials
through vacuole-mediated sequestration and subsequent delivery to lysosomes for …

Mesenchymal stem cells (MSCs) have been reported to exert therapeutic effects on
immunoregulation, tissue repair, and regeneration from the bench to the bedside. Increasing …

Hepatic ischemia and reperfusion injury are characterized by impaired autophagy,
mitochondrial dysfunction, and subsequent compromise of cellular homeostasis following …

Liver ischemia‐reperfusion (I‐R) injury occurs during liver resection, liver transplantation,
and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I‐R is …

Ischemia/reperfusion (I/R) injury remains a major complication of liver resection,
transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic …

Autophagy, an important intracellular degradation pathway, has been reported to clear
impaired mitochondria and reduce mitochondria-mediated injury in ischemic disease. Our …

Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the
material has other bioactivities; for example, it accelerates angiogenesis, has anti …

Ischemia-reperfusion (IR) injury is an inevitable complication of liver transplantation and
partial hepatectomy. Although the hazards of environmental microplastics (EMPs) have …

Transient ischaemia and reperfusion in liver tissue induce hepatic ischaemia/reperfusion
(I/R) tissue injury and a profound inflammatory response in vivo. Hepatic I/R can be …