5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines
R Aggarwal, S Kumar - Beilstein Journal of Organic Chemistry, 2018 - beilstein-journals.org
The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …
Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors
MS Alesawy, AA Al‐Karmalawy… - Archiv Der …, 2021 - Wiley Online Library
Abstract A new series of 1, 2, 4‐triazolo [4, 3‐c] quinazoline derivatives was designed and
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …
An assessment study of known pyrazolopyrimidines: Chemical methodology and cellular activity
RN Rao, K Chanda - Bioorganic Chemistry, 2020 - Elsevier
Heterocyclic compounds with nitrogen atom play a key role in the normal life cycle of a cell.
Pyrazolopyrimidine is a privileged class of nitrogen containing fused heterocyclic compound …
Pyrazolopyrimidine is a privileged class of nitrogen containing fused heterocyclic compound …
Design, synthesis and anticancer evaluation of 1H-pyrazolo [3, 4-d] pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers
In our attempt to develop effective EGFR-TKIs, two series of 1H-pyrazolo [3, 4-d] pyrimidine
derivatives were designed and synthesized. All the newly synthesized compounds were …
derivatives were designed and synthesized. All the newly synthesized compounds were …
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxaline and bis ([1, 2, 4] triazolo)[4, 3-a:
3′, 4′-c] quinoxaline derivatives have been designed, synthesized and biologically …
3′, 4′-c] quinoxaline derivatives have been designed, synthesized and biologically …
Design, synthesis and evaluation of some pyrazolo [3, 4-d] pyrimidines as anti-inflammatory agents
GN Tageldin, SM Fahmy, HM Ashour, MA Khalil… - Bioorganic …, 2018 - Elsevier
Abstract New pyrazolo [3, 4-d] pyrimidines substituted with various functionalities or attached
to a substituted pyrazole ring through different linkages were synthesized. The synthesized …
to a substituted pyrazole ring through different linkages were synthesized. The synthesized …
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by …
AKB Aljohani, WAZ El Zaloa, M Alswah… - International journal of …, 2023 - mdpi.com
Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
Synthesis and evaluation of thiazolidinone–pyrazole conjugates as anticancer and antimicrobial agents
M Bhat, B Poojary, BS Kalal… - Future Medicinal …, 2018 - Taylor & Francis
Aim: To synthesize a series of new thiazolidinone–pyrazole hybrids (5a–o) and assess their
anticancer (in vitro and in vivo) and antimicrobial activities. Results: The compounds 5h …
anticancer (in vitro and in vivo) and antimicrobial activities. Results: The compounds 5h …
A molecular insight into pyrazole congeners as antimicrobial, anticancer, and antimalarial agents
D Karati, KR Mahadik, P Trivedi… - Medicinal …, 2022 - ingentaconnect.com
Background: Pyrazole is a bioactive heterocyclic congener with numerous biological and
pharmacological functionalities. Due to their multiple prospective applications, developing …
pharmacological functionalities. Due to their multiple prospective applications, developing …
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia
Y Zhang, X Wu, X Sun, J Yang, C Liu… - Mini Reviews in …, 2024 - ingentaconnect.com
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According
to the American Cancer Society's 2021 cancer data report, new cases of CML account for …
to the American Cancer Society's 2021 cancer data report, new cases of CML account for …