The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …

Abstract A new series of 1, 2, 4‐triazolo [4, 3‐c] quinazoline derivatives was designed and
synthesized as Topo II inhibitors and DNA intercalators. The cytotoxic effect of the new …

Heterocyclic compounds with nitrogen atom play a key role in the normal life cycle of a cell.
Pyrazolopyrimidine is a privileged class of nitrogen containing fused heterocyclic compound …

In our attempt to develop effective EGFR-TKIs, two series of 1H-pyrazolo [3, 4-d] pyrimidine
derivatives were designed and synthesized. All the newly synthesized compounds were …

Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxaline and bis ([1, 2, 4] triazolo)[4, 3-a:
3′, 4′-c] quinoxaline derivatives have been designed, synthesized and biologically …

Abstract New pyrazolo [3, 4-d] pyrimidines substituted with various functionalities or attached
to a substituted pyrazole ring through different linkages were synthesized. The synthesized …

Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …

Aim: To synthesize a series of new thiazolidinone–pyrazole hybrids (5a–o) and assess their
anticancer (in vitro and in vivo) and antimicrobial activities. Results: The compounds 5h …

Background: Pyrazole is a bioactive heterocyclic congener with numerous biological and
pharmacological functionalities. Due to their multiple prospective applications, developing …

Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According
to the American Cancer Society's 2021 cancer data report, new cases of CML account for …