Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
Regulatory T cells in autoimmune disease
M Dominguez-Villar, DA Hafler - Nature immunology, 2018 - nature.com
In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …
considerably. Key observations have challenged the traditional definition of Treg cells and …
[HTML][HTML] Control of human toxoplasmosis
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
Interferon-γ drives Treg fragility to promote anti-tumor immunity
Regulatory T cells (T regs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is
required to maintain intratumoral T reg stability and function but is dispensable for peripheral …
required to maintain intratumoral T reg stability and function but is dispensable for peripheral …
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
N Ohkura, S Sakaguchi - Cell research, 2020 - nature.com
Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
T helper cell differentiation, heterogeneity, and plasticity
J Zhu - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
M DuPage, JA Bluestone - Nature Reviews Immunology, 2016 - nature.com
CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …
can also adapt their functions in response to changing circumstances. Although this …
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
N Komatsu, K Okamoto, S Sawa, T Nakashima… - Nature medicine, 2014 - nature.com
Autoimmune diseases often result from an imbalance between regulatory T (Treg) cells and
interleukin-17 (IL-17)-producing T helper (TH17) cells; the origin of the latter cells remains …
interleukin-17 (IL-17)-producing T helper (TH17) cells; the origin of the latter cells remains …
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
W Liao, JX Lin, WJ Leonard - Immunity, 2013 - cell.com
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …