[PDF][PDF] Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
[HTML][HTML] Deciphering cell–cell interactions and communication from gene expression
E Armingol, A Officer, O Harismendy… - Nature Reviews …, 2021 - nature.com
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …
supports normal tissue turnover and can mount a regenerative response following acute …
[HTML][HTML] Multimodal analysis of composition and spatial architecture in human squamous cell carcinoma
To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …
[HTML][HTML] Chromatin potential identified by shared single-cell profiling of RNA and chromatin
Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …
including modulation of gene expression by changes in chromatin accessibility. However …
Developmental cell programs are co-opted in inflammatory skin disease
G Reynolds, P Vegh, J Fletcher, EFM Poyner… - Science, 2021 - science.org
INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …
insult through structural adaptations and interplay with the innate and adaptive immune …
[HTML][HTML] Statistical and machine learning methods for spatially resolved transcriptomics data analysis
The recent advancement in spatial transcriptomics technology has enabled multiplexed
profiling of cellular transcriptomes and spatial locations. As the capacity and efficiency of the …
profiling of cellular transcriptomes and spatial locations. As the capacity and efficiency of the …
Single-cell transcriptional diversity is a hallmark of developmental potential
GS Gulati, SS Sikandar, DJ Wesche, A Manjunath… - Science, 2020 - science.org
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
[PDF][PDF] Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells
DA Michelson, K Hase, T Kaisho, C Benoist, D Mathis - Cell, 2022 - cell.com
Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …
[HTML][HTML] Inferring spatial and signaling relationships between cells from single cell transcriptomic data
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however,
crucial spatial information is often lost. We present SpaOTsc, a method relying on structured …
crucial spatial information is often lost. We present SpaOTsc, a method relying on structured …