More frequent and intense periods of extreme heat (heatwaves) represent the most direct
challenge to human health posed by climate change. Older adults are particularly …

Calcium, phosphorus, and magnesium homeostasis is altered in chronic kidney disease
(CKD). Hypocalcemia, hyperphosphatemia, and hypermagnesemia are not seen until …

Normal adult humans eating Western diets have chronic, low-grade metabolic acidosis, the
severity of which is determined in part by the net rate of endogenous noncarbonic acid …

The average American diet, which is high in protein and low in fruits and vegetables,
generates a large amount of acid, mainly as sulfates and phosphates. The kidneys respond …

Osteoporosis is an ageing disorder characterised by poor microstructural architecture of the
bone and an increase in the risk of fragility fractures, which often leads to hospitalisation and …

Background: Different sources of dietary protein may have different effects on bone
metabolism. Animal foods provide predominantly acid precursors, whereas protein in …

Bone homeostasis is profoundly affected by local pH and oxygen tension. It has long been
recognised that the skeleton contains a large reserve of alkaline mineral (hydroxyapatite) …

Metabolic acidosis is noted in the majority of patients with chronic kidney disease (CKD)
when glomerular filtration rate (GFR) decreases to less than 20% to 25% of normal, although …

Extensively revised and updated to reflect the current state of knowledge in the study of
aging, the third edition of the bestselling Physiological Basis of Aging and Geriatrics …

Background & aims Age-related physiological changes predispose even the healthy older
adult to fluid and electrolyte abnormalities which can cause morbidity and mortality. The aim …