Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Parkinson disease (PD) is a neurodegenerative disorder characterized by dopaminergic
neurons affected by inflammatory processes. Post-mortem analyses of brain and …

Neurogenesis, a process of generation of new neurons, is reported to be reduced in several
neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis …

The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …

Background Stem cells hold tremendous promise for regenerative medicine because they
can be expanded infinitely, giving rise to large numbers of differentiated cells required for …

An important pathophysiological component of Parkinson's Disease (PD) is circadian rhythm
disorder, closely related to a decrease in circulated melatonin (MLT) level. It has been …

Abstract Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has
low toxicity and has been shown to have neuroprotective effects. The objectives of the …

In the adult hippocampus, new neurons are generated in the dentate gyrus. The Wnt
signaling pathway regulates this process, but little is known about the endogenous Wnt …

Human pluripotent stem cell–based (hPSC-based) replacement therapy holds great promise
for the treatment of Parkinson's disease (PD). However, the heterogeneity of hPSC-derived …