Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

The global prevalence of migraine as a primary headache has been estimated as 14.4% in
both sexes. Migraine headache has been ranked as the highest contributor to disability in …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

The most important primary headaches (ie independent disorders that are not caused by
another disease) are migraine, tension-type headache and cluster headache. All primary …

Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …