Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

Antibiotic pollution in surface fresh waters: Occurrence and effects

MC Danner, A Robertson, V Behrends… - Science of the total …, 2019 - Elsevier
Abstract Worldwide, antibiotic usage exceeds 100,000 tons per year and there is increasing
concern over the fate of these substances. Antibiotics are ubiquitous in the environment and …

Environmental factors influencing the development and spread of antibiotic resistance

J Bengtsson-Palme, E Kristiansson… - FEMS microbiology …, 2018 - academic.oup.com
Antibiotic resistance and its wider implications present us with a growing healthcare crisis.
Recent research points to the environment as an important component for the transmission …

[HTML][HTML] Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

DGJ Larsson, A Andremont, J Bengtsson-Palme… - Environment …, 2018 - Elsevier
There is growing understanding that the environment plays an important role both in the
transmission of antibiotic resistant pathogens and in their evolution. Accordingly …

[HTML][HTML] Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance

PJ Vikesland, A Pruden, PJJ Alvarez, D Aga… - 2017 - ACS Publications
Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance,
it is necessary to consider all possible sources and understand the pathways and …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - Am Soc Microbiol
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

[HTML][HTML] Tackling antibiotic resistance with compounds of natural origin: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán, V Micol - Biomedicines, 2020 - mdpi.com
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …

The complexity of urban eco-evolutionary dynamics

M Alberti, EP Palkovacs, SD Roches, LD Meester… - …, 2020 - academic.oup.com
Urbanization is changing Earth's ecosystems by altering the interactions and feedbacks
between the fundamental ecological and evolutionary processes that maintain life. Humans …