Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

While obesity and associated metabolic complications are linked to inflammation of white
adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local …

The ability of growth hormone (GH) to induce adipose tissue lipolysis has been known for
over five decades; however, the molecular mechanisms that mediate this effect and the …

The adipose organ comprises two main fat depots termed white and brown adipose tissues.
Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor …

Human skin dermis is composed of the superficial papillary dermis and the reticular dermis
in the lower layers, which can easily be distinguished histologically. In vitro analyses of …

Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new
adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene …