At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

The rodent whisker-to-barrel cortex pathway is a classic model to study the effects of sensory
experience and deprivation on neuronal circuit formation, not only during development but …

The propagation of electrical impulses along axons is highly accelerated by the myelin
sheath and produces saltating or" jumping" action potentials across internodes, from one …

The axon initial segment (AIS) is a critical microdomain for action potential initiation and
implicated in the regulation of neuronal excitability during activity-dependent plasticity. While …

Biological neurons show significant cell-to-cell variability but have the striking ability to
maintain their key firing properties in the face of unpredictable perturbations and stochastic …

Abstract Parvalbumin-expressing (PV+) basket cells are fast-spiking inhibitory interneurons
that exert critical control over local circuit activity and oscillations. PV+ axons are often …

In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial
segment (AIS). Both position and length of the AIS vary across and within neuron types, with …

Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The
cellular basis of hyperexcitability and how it responds to changing activity states is not fully …

The canonical view of neuronal function is that inputs are received by dendrites and somata,
become integrated in the somatodendritic compartment and upon reaching a sufficient …

Voltage-dependent conductances not only drive action potentials but also help regulate
neuronal resting potential. We found differential regulation of resting potential in the …