Regulation of pyruvate metabolism and human disease
LR Gray, SC Tompkins, EB Taylor - Cellular and molecular life sciences, 2014 - Springer
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
Toward an understanding of the structural and mechanistic aspects of protein-protein interactions in 2-oxoacid dehydrogenase complexes
The 2-oxoglutarate dehydrogenase complex (OGDHc) is a key enzyme in the tricarboxylic
acid (TCA) cycle and represents one of the major regulators of mitochondrial metabolism …
acid (TCA) cycle and represents one of the major regulators of mitochondrial metabolism …
Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
Found across all kingdoms of life, 2-keto acid dehydrogenase complexes possess
prominent metabolic roles and form major regulatory sites. Although their component …
prominent metabolic roles and form major regulatory sites. Although their component …
[图书][B] Studies in natural products chemistry
A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients
H Pavlu-Pereira, MJ Silva, C Florindo… - Orphanet Journal of …, 2020 - Springer
Background The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible
decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in …
decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in …
Matchout deuterium labelling of proteins for small-angle neutron scattering studies using prokaryotic and eukaryotic expression systems and high cell-density cultures
O Dunne, M Weidenhaupt, P Callow, A Martel… - European Biophysics …, 2017 - Springer
Small-angle neutron scattering (SANS) is a powerful technique for the characterisation of
macromolecular structures and interactions. Its main advantage over other solution state …
macromolecular structures and interactions. Its main advantage over other solution state …
[图书][B] Molecular biology of assemblies and machines
A Steven, W Baumeister, LN Johnson, RN Perham - 2016 - taylorfrancis.com
Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the
ways in which macromolecular structures assemble and how they interact with other …
ways in which macromolecular structures assemble and how they interact with other …
Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
The pyruvate dehydrogenase complex (PDC) is a multienzyme complex central to aerobic
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Similar to the E3 …
respiration, connecting glycolysis to mitochondrial oxidation of pyruvate. Similar to the E3 …
Structural and functional analyses of the human PDH complex suggest a “division-of-labor” mechanism by local E1 and E3 clusters
The pseudo-atomic structural model of human pyruvate dehydrogenase complex (PDHc)
core composed of full-length E2 and E3BP components, calculated from our cryoelectron …
core composed of full-length E2 and E3BP components, calculated from our cryoelectron …
Redox-driven signaling: 2-oxo acid dehydrogenase complexes as sensors and transmitters of metabolic imbalance
VI Bunik - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: This article develops a holistic view on production of reactive oxygen species
(ROS) by 2-oxo acid dehydrogenase complexes. Recent Advances: Catalytic and structural …
(ROS) by 2-oxo acid dehydrogenase complexes. Recent Advances: Catalytic and structural …