Direct Methane Oxidation by Copper-and Iron-Dependent Methane Monooxygenases

FJ Tucci, AC Rosenzweig - Chemical reviews, 2024 - ACS Publications
Methane is a potent greenhouse gas that contributes significantly to climate change and is
primarily regulated in Nature by methanotrophic bacteria, which consume methane gas as …

Discovery of new enzymatic functions and metabolic pathways using genomic enzymology web tools

R Zallot, N Oberg, JA Gerlt - Current opinion in biotechnology, 2021 - Elsevier
The continuing expansion of protein and genome sequence databases is an opportunity to
identify novel enzymes with biotechnological applications. Whether applied to enzymology …

[HTML][HTML] Bacterial peroxidases–Multivalent enzymes that enable the use of hydrogen peroxide for microaerobic and anaerobic proliferation

DS Barreiro, RNS Oliveira, SR Pauleta - Coordination Chemistry Reviews, 2023 - Elsevier
Bacterial peroxidases are responsible for the reduction of hydrogen peroxide to water.
Found in the periplasm of gram-negative bacteria, they are one of the defense mechanisms …

Methanobactins: Structures, Biosynthesis, and Microbial Diversity

RM Reyes, AC Rosenzweig - Annual review of microbiology, 2024 - annualreviews.org
Methanobactins (Mbns) are ribosomally synthesized and posttranslationally modified
peptide natural products released by methanotrophic bacteria under conditions of copper …

Heterologous Biosynthesis of Methanobactin from Methylocystis sp. Strain SB2 in Methylosinus trichosporium OB3b

P Peng, AA DiSpirito, BJ Lewis, JD Nott… - ACS Synthetic …, 2024 - ACS Publications
Aerobic methanotrophs, or methane-consuming microbes, are strongly dependent on
copper for their activity. To satisfy this requirement, some methanotrophs produce a copper …

Copper binding by a unique family of metalloproteins is dependent on kynurenine formation

AC Manesis, RJ Jodts, BM Hoffman… - Proceedings of the …, 2021 - National Acad Sciences
Some methane-oxidizing bacteria use the ribosomally synthesized, posttranslationally
modified natural product methanobactin (Mbn) to acquire copper for their primary metabolic …

Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH

AC Manesis, JW Slater, K Cantave… - Biochemistry, 2023 - ACS Publications
The diheme bacterial cytochrome c peroxidase (bC c P)/MauG superfamily is a diverse set of
enzymes that remains largely uncharacterized. One recently discovered member, MbnH …

Spectroscopic insights into the mechanism of anammox hydrazine synthase

W Versantvoort, R Hienerwadel, C Ferousi… - bioRxiv, 2023 - biorxiv.org
Anaerobic ammonium oxidizing bacteria make a living oxidizing ammonium with nitrite as
electron acceptor, intermediates nitric oxide and hydrazine, and end product dinitrogen gas …