Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

A series of tools for targeted protein degradation are inspiring scientists to develop new
drugs with advantages over traditional small-molecule drugs. Among these tools, proteolysis …

In recent years, gene therapy has been raising hopes toward viable treatment strategies for
rare genetic diseases for which there has been almost exclusively supportive treatment. We …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Although the aetiology of amyotrophic lateral sclerosis (ALS) remains poorly understood,
impaired proteostasis is a common feature of different forms of ALS. Mutations in genes …

The main aim of this review is to summarize the current state-of-art in the field of childhood
Neuronal Ceroid Lipofuscinosis (NCL), a group of rare neurodegenerative disorders. These …

Lysosomes play major roles in growth regulation and catabolism and are recognized as
critical mediators of cellular remodeling. An emerging theme is how the lysosome is itself …

The sorting of soluble secretory proteins from the endoplasmic reticulum (ER) to the Golgi
complex is mediated by coat protein complex II (COPII) vesicles and thought to required …