Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

Being overweight increases the risk of many metabolic disorders, but how it affects lifespan
is not completely clear. Not all obese people become ill, and the exact mechanism that turns …

Abstract Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in
recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous …

Neutral lipid metabolism is a key aspect of intracellular homeostasis and energy balance
and plays a vital role in cell survival under adverse conditions, including nutrient deprivation …

Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not
understood. The protective effects of the APOE 2 on Alzheimer's disease (AD) risk …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Adipocytes store nutrients as lipid droplets (LDs), but how they organize their LD stores to
balance lipid uptake, storage, and mobilization remains poorly understood. Here, using …

There is growing interest in pharmacological interventions directly targeting the aging
process. Pharmacological interventions against aging should be efficacious when started in …

Triacylglycerol (TAG) is among the most energy dense storage forms of reduced carbon in
living systems. TAG metabolism plays critical roles in cellular energy balance, lipid …

Cellular replicative senescence, a state of permanent cell-cycle arrest, has been linked to
organismal aging, tissue repair and tumorigenesis. In this study, we comparatively …