The GPCR Network: a large-scale collaboration to determine human GPCR structure and function
G protein-coupled receptors (GPCRs) are targeted by∼ 30–40% of marketed drugs, and
their key roles in normal physiology and in disease demonstrate that an understanding of …
their key roles in normal physiology and in disease demonstrate that an understanding of …
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence
The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
Structural basis for allosteric regulation of GPCRs by sodium ions
Pharmacological responses of G protein–coupled receptors (GPCRs) can be fine-tuned by
allosteric modulators. Structural studies of such effects have been limited due to the medium …
allosteric modulators. Structural studies of such effects have been limited due to the medium …
Identification of novel chemical entities for adenosine receptor type 2a using molecular modeling approaches
Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-
inflammatory ones. In this way, the present work aimed to search for compounds by …
inflammatory ones. In this way, the present work aimed to search for compounds by …
Targeting adenosine A2A receptor antagonism for treatment of cancer
M Congreve, GA Brown, A Borodovsky… - Expert opinion on drug …, 2018 - Taylor & Francis
ABSTRACT Introduction: Adenosine A2A Receptor (A2AR) antagonists are an emerging
class of agents that treat cancers, both as a monotherapy and in combination with other …
class of agents that treat cancers, both as a monotherapy and in combination with other …
Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor
A prospective, large library virtual screen against an activated β2-adrenergic receptor
(β2AR) structure returned potent agonists to the exclusion of inverse-agonists, providing the …
(β2AR) structure returned potent agonists to the exclusion of inverse-agonists, providing the …
Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists
A Jazayeri, SP Andrews, FH Marshall - Chemical reviews, 2017 - ACS Publications
Over the past decade there has been a revolution in the field of G protein-coupled receptor
(GPCR) structural biology. Many years of innovative research from different areas have …
(GPCR) structural biology. Many years of innovative research from different areas have …
Molecular Docking Screening Using Agonist-Bound GPCR Structures: Probing the A2A Adenosine Receptor
D Rodríguez, ZG Gao, SM Moss… - Journal of chemical …, 2015 - ACS Publications
Crystal structures of G protein-coupled receptors (GPCRs) have recently revealed the
molecular basis of ligand binding and activation, which has provided exciting opportunities …
molecular basis of ligand binding and activation, which has provided exciting opportunities …
Structure‐based and fragment‐based GPCR drug discovery
SP Andrews, GA Brown, JA Christopher - ChemMedChem, 2014 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are an important family of membrane proteins;
historically, drug discovery in this target class has been fruitful, with many of the world's top …
historically, drug discovery in this target class has been fruitful, with many of the world's top …
Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions
DK Tosh, F Deflorian, K Phan, ZG Gao… - Journal of medicinal …, 2012 - ACS Publications
(N)-Methanocarba adenosine 5′-methyluronamides containing known A3 AR (adenosine
receptor)-enhancing modifications, ie, 2-(arylethynyl) adenine and N 6-methyl or N 6-(3 …
receptor)-enhancing modifications, ie, 2-(arylethynyl) adenine and N 6-methyl or N 6-(3 …