The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

With the financial requirements and high time associated with bringing a commercial drug to
the market, the application of computer-aided drug design has been recognized as a …

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …

Human dopamine transporter (hDAT) regulates the reuptake of extracellular dopamine (DA)
and is an essential therapeutic target for central nervous system (CNS) diseases. The …

Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …

Abstract Background Omicron (B. 1.1. 529), a variant of SARS-CoV-2 is currently spreading
globally as a dominant strain. Due to multiple mutations at its Spike protein, including 15 …

Vitamin D deficiency is associated with a higher risk of SARS-CoV-2 infection and poor
outcomes of the COVID-19 disease. However, a satisfactory mechanism explaining the …

The outbreak caused by SARS-CoV-2 has received extensive worldwide attention. As the
main protease (Mpro) in SARS-CoV-2 has no human homologues, it is feasible to reduce …