Metabolic phenotyping is an important tool in translational biomedical research. The
advanced analytical technologies commonly used for phenotyping, including mass …

The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

Metabonomics is a key element in systems biology, and with current analytical methods,
generates vast amounts of quantitative or qualitative metabolic data. Understanding of the …

Estimation of statistical power and sample size is a key aspect of experimental design.
However, in metabolic phenotyping, there is currently no accepted approach for these tasks …

This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a
model organism for chemists interested in studying living systems. C. elegans, a 1 mm long …

The nematode Caenorhabditis elegans is widely used as a model organism in many areas
of the life sciences. Metabolite profiling (metabolomics/metabonomics) is a powerful means …

Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and
nutritional framework is rapidly being uncovered, particularly using C. elegans as a model …

The world faces complex challenges for chemical hazard assessment. Microfluidic
bioartificial organs enable the spatial and temporal control of cell growth and biochemistry …

The ubiquity of lipids in biological structures and functions suggests that lipid metabolisms
are highly regulated. However, current invasive techniques for lipid studies prevent …