One hundred and fifty years since Nikolaus Friedreich's first description of the degenerative
ataxic syndrome which bears his name, his description remains at the core of the classical …

Friedreich ataxia, an autosomal recessive neurodegenerative disease, is the most common
of the inherited ataxias. The recent discovery of the gene that is mutated in this condition …

Friedreich's ataxia is the most common inherited ataxia. Ninety‐six percent of patients are
homozygous for GAA trinucleotide repeat expansions in the first intron of the frataxin gene …

Friedreich ataxia (FRDA), an autosomal recessive, neurodegenerative disease is the most
common inherited ataxia. The vast majority of patients are homozygous for an abnormal …

A novel DNA structure, sticky DNA, is described for lengths of (GAA· TTC) n found in intron 1
of the frataxin gene of Friedreich's ataxia patients. Sticky DNA is formed by the association of …

Friedreich ataxia is the most frequent hereditary ataxia, with an estimated prevalence of 3–4
cases per 100,000 individuals. This autosomal-recessive neurodegenerative disease is …

Article abstract Increased generation of reactive oxygen species may underlie the
pathophysiology of Friedreich ataxia (FRDA). The authors measured concentrations of 8 …

Abstract Treatment of motor symptoms of degenerative cerebellar ataxia remains difficult.
Yet there are recent developments that are likely to lead to significant improvements in the …

Background Mutations in SACS, leading to autosomal-recessive spastic ataxia of Charlevoix-
Saguenay (ARSACS), have been identified as a frequent cause of recessive early-onset …

The nosology and aetiology of sporadic adult‐onset ataxia are poorly understood. The aim
of the present study was to answer the following questions:(i) How many sporadic ataxia …