Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by
telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and …

ABSTRACT TIN2 is an important regulator of telomere length, and mutations in TINF2, the
gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the …

Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an
essential component of telomere integrity and telomerase function. A surface on the OB …

Highlights•First cryo-EM structure of telomerase, from Tetrahymena, at∼ 9 Å resolution.•New
TERT and TER domain structures and interactions.•RPA-like proteins bridge the telomerase …

Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC 1, a
component of the CST (CTC 1, STN 1, and TEN 1) complex important for telomere length …