Mucosal immunity to pathogenic intestinal bacteria

A Perez-Lopez, J Behnsen, SP Nuccio… - Nature Reviews …, 2016 - nature.com
The intestinal mucosa is a particularly dynamic environment in which the host constantly
interacts with trillions of commensal microorganisms, known as the microbiota, and …

Preharvest transmission routes of fresh produce associated bacterial pathogens with outbreak potentials: a review

CD Iwu, AI Okoh - International journal of environmental research and …, 2019 - mdpi.com
Disease outbreaks caused by the ingestion of contaminated vegetables and fruits pose a
significant problem to human health. The sources of contamination of these food products at …

Salmonella pathogenicity and host adaptation in chicken-associated serovars

SL Foley, TJ Johnson, SC Ricke, R Nayak… - Microbiology and …, 2013 - Am Soc Microbiol
Enteric pathogens such as Salmonella enterica cause significant morbidity and mortality. S.
enterica serovars are a diverse group of pathogens that have evolved to survive in a wide …

Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation

R Di Niro, SJ Lee, JA Vander Heiden, RA Elsner… - Immunity, 2015 - cell.com
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular
sites, without notable germinal centers (GCs). Little is known in terms of its specificity. To …

Vaccines against invasive Salmonella disease: Current status and future directions

CA MacLennan, LB Martin, F Micoli - Human vaccines & …, 2014 - Taylor & Francis
Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet
under-appreciated global burden of invasive disease. In South and South-East Asia, this …

Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

FM Key, C Posth, LR Esquivel-Gomez… - Nature ecology & …, 2020 - nature.com
It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist
economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight …

Protective Host Immune Responses to Salmonella Infection

OH Pham, SJ McSorley - Future microbiology, 2015 - Taylor & Francis
Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human
typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic …

Immunization with the yersiniabactin receptor, FyuA, protects against pyelonephritis in a murine model of urinary tract infection

AR Brumbaugh, SN Smith, HLT Mobley - Infection and immunity, 2013 - Am Soc Microbiol
Urinary tract infections (UTI) are common and represent a substantial economic and public
health burden. Roughly 80% of these infections are caused by a heterogeneous group of …

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

CC Domínguez-Medina, M Pérez-Toledo… - Nature …, 2020 - nature.com
Abstract Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to
surface antigens, although the relationship between antibody, O-Ag and other outer …

Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo

WW Hui, LE Emerson, B Clapp, AE Sheppe… - PLoS …, 2021 - journals.plos.org
Salmonella Typhimurium is a causative agent of nontyphoidal salmonellosis, for which there
is a lack of a clinically approved vaccine in humans. As an intracellular pathogen …