Pharmacological targeting of endoplasmic reticulum stress in disease
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
The integrated stress response: From mechanism to disease
M Costa-Mattioli, P Walter - Science, 2020 - science.org
BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …
[HTML][HTML] Stress response silencing by an E3 ligase mutated in neurodegeneration
DL Haakonsen, M Heider, AJ Ingersoll, K Vodehnal… - Nature, 2024 - nature.com
Stress response pathways detect and alleviate adverse conditions to safeguard cell and
tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts …
tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts …
[HTML][HTML] Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
Maternal immune activation in mice disrupts proteostasis in the fetal brain
Maternal infection and inflammation during pregnancy are associated with
neurodevelopmental disorders in offspring, but little is understood about the molecular …
neurodevelopmental disorders in offspring, but little is understood about the molecular …
[HTML][HTML] The science of puromycin: From studies of ribosome function to applications in biotechnology
R Aviner - Computational and Structural Biotechnology Journal, 2020 - Elsevier
Puromycin is a naturally occurring aminonucleoside antibiotic that inhibits protein synthesis
by ribosome-catalyzed incorporation into the C-terminus of elongating nascent chains …
by ribosome-catalyzed incorporation into the C-terminus of elongating nascent chains …
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease
Neuronal protein synthesis is essential for long-term memory consolidation, and its
dysregulation is implicated in various neurodegenerative disorders, including Alzheimer's …
dysregulation is implicated in various neurodegenerative disorders, including Alzheimer's …
[HTML][HTML] Adapting the proteostasis capacity to sustain brain healthspan
C Hetz - Cell, 2021 - cell.com
Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …
RNA-binding proteins balance brain function in health and disease
R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …
decay provides an important regulatory layer in many if not all molecular pathways …
[HTML][HTML] ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B
AF Zyryanova, K Kashiwagi, C Rato, HP Harding… - Molecular cell, 2021 - cell.com
The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR)
by phosphorylated translation initiation factor 2, eIF2 (αP). ISRIB and eIF2 (αP) bind distinct …
by phosphorylated translation initiation factor 2, eIF2 (αP). ISRIB and eIF2 (αP) bind distinct …