UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

This review focuses primarily on the beneficial effects for human health of exposure to
ultraviolet radiation (UVR). UVR stimulates anti-inflammatory and immunosuppressive …

Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …

The JAK-STAT signaling pathway mediates important cellular processes such as immune
response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that …

It is still unknown whether the human interfollicular epidermis harbors a reservoir of
melanocyte precursor cells. Here, we clearly distinguish between three distinct types of …

Vitiligo is a common chronic skin disease which has an adverse impact on patients' life. Its
pathogenesis is complex, involving autoimmunity and oxidative stress (OS). Autoimmunity …

Variation in human skin and hair color is the most notable aspect of human variability and
several studies in evolution, genetics and developmental biology contributed to explain the …

Vitiligo is the most frequent human pigmentary disorder, characterized by progressive
autoimmune destruction of mature epidermal melanocytes. Of the current treatments offering …

Objective To evaluate the clinical efficacy and safety of baricitinib, a Janus kinase (JAK)
inhibitor, in treating patient with progressing vitiligo, and to further explore the regulation of …

This study aimed to investigate the protective effect of NAcM‐OPT, a small molecule inhibitor
of defective in cullin neddylation 1 (DCN1), on H2O2‐induced oxidative damage in …