Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Forsythiae Fructus, the dried …

Cancer is the second leading cause of death globally. Millions of persons die due to cancer
each year. In the last two decades, the anticancer effects of natural flavonoids have become …

Microplastics are ubiquitous environmental pollutants that are a growing concern to many
ecosystems, as well as human health. Many of the effects of microplastics on mammalian …

Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

Toll-like receptors (TLRs) are a family of pattern recognition receptors that initiate signaling
in innate and adaptive immune pathways. The highly conserved family of transmembrane …

Inflammatory damage plays an important role in cerebral ischemic pathogenesis and
represents a new target for treatment of stroke. Berberine is a natural medicine with multiple …

Sorafenib is an anti-tumor drug widely used in clinical treatment, which can inhibit tyrosine
kinase receptor on cell surface and serine/threonine kinase in downstream Ras/MAPK …