Papillomaviridae is a family of small non-enveloped icosahedral viruses with double-
stranded circular DNA. More than 200 different human papillomaviruses (HPVs) have been …

Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

H19 is an imprinted long noncoding RNA abundantly expressed in embryonic liver and
repressed after birth. We show that H19 serves as a lipid sensor by synergizing with the …

Posttranscriptional modifications in RNA have been considered to contribute to disease
pathogenesis and tumor progression. NOL1/NOP2/Sun domain family member 2 (NSUN2) …

The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and
outside the nucleus. However, it is currently unclear whether and how the distribution of …

A salient feature of alcoholic liver disease (ALD) is Kupffer cell (KC) activation and
recruitment of inflammatory monocytes and macrophages (MØs). These key cellular events …

The loss of epithelial cell polarity plays an important role in the development and
progression of liver cancer. However, the specific molecular mechanisms supporting tumor …

Breast cancer is one of the most common malignant tumors with high mortality due to
metastases. SCRIB, a scaffold protein mainly distributed in the cell membrane, is a potential …

The interaction between proteins is a fundamental event for cellular life that is generally
mediated by specialized protein domains or modules. PDZ domains are the largest class of …