Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Cancer develops when the balance between cell proliferation and cell death is disrupted,
and the ensuing aberrant proliferation leads to tumor growth. The cyclin-dependent kinase …

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …

The activation of cellular senescence throughout the lifespan promotes tumor suppression,
whereas the persistence of senescent cells contributes to aspects of aging. This theory has …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert
beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

Members of the suppressor of cytokine signaling (SOCS) family are potentially key
physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether …

To thwart viral infection, the host has developed a formidable and integrated defense
network that comprises our innate and adaptive immune response. In recent years, it has …

The molecular pathways involved in the cellular response to interferon (IFN) γ have been the
focus of much research effort due to their importance in host defense against infection and …