HERC5 and the ISGylation pathway: critical modulators of the antiviral immune response
Mammalian cells have developed an elaborate network of immunoproteins that serve to
identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa …
identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa …
[HTML][HTML] The HERC proteins and the nervous system
EM Pérez-Villegas, R Ruiz, S Bachiller… - Seminars in cell & …, 2022 - Elsevier
The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …
ISG15 deficiency restricts HIV-1 infection
D Jurczyszak, L Manganaro, S Buta, C Gruber… - PLoS …, 2022 - journals.plos.org
Type I interferons (IFN-Is) are a group of potent inflammatory and antiviral cytokines. They
induce IFN stimulated genes (ISGs), which act as proinflammatory mediators, antiviral …
induce IFN stimulated genes (ISGs), which act as proinflammatory mediators, antiviral …
Screening biomarkers for systemic lupus erythematosus based on machine learning and exploring their expression correlations with the ratios of various immune cells
Y Zhong, W Zhang, X Hong, Z Zeng, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Background Systemic lupus erythematosus (SLE) is an autoimmune illness caused by a
malfunctioning immunomodulatory system. China has the second highest prevalence of SLE …
malfunctioning immunomodulatory system. China has the second highest prevalence of SLE …
Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control …
HK Li, M Kaforou, J Rodriguez-Manzano… - The Lancet …, 2021 - thelancet.com
Background Emergency admissions for infection often lack initial diagnostic certainty.
COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of …
COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of …
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren's syndrome
H Luo, X Zhou - Frontiers in Immunology, 2022 - frontiersin.org
Background Accumulating evidence has revealed that the prevalence of Coronavirus 2019
(COVID-19) was significantly higher in patients with primary Sjogren's syndrome (pSS) …
(COVID-19) was significantly higher in patients with primary Sjogren's syndrome (pSS) …
Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma—A meta-analysis approach
Head and neck squamous cell carcinomas (HNSCC) includes multiple subsites that exhibit
differential treatment outcome, which is in turn reflective of tumor stage/histopathology and …
differential treatment outcome, which is in turn reflective of tumor stage/histopathology and …
Rapid evolution of HERC6 and duplication of a chimeric HERC5/6 gene in rodents and bats suggest an overlooked role of HERCs in mammalian immunity
S Jacquet, D Pontier, L Etienne - Frontiers in immunology, 2020 - frontiersin.org
Studying the evolutionary diversification of mammalian antiviral defenses is of main
importance to better understand our innate immune repertoire. The small HERC proteins are …
importance to better understand our innate immune repertoire. The small HERC proteins are …
A novel non–mammalian-specific HERC7 negatively regulates IFN response through degrading RLR signaling factors
YL Li, XY Gong, ZL Qu, X Zhao, C Dan… - The Journal of …, 2022 - journals.aai.org
The small HERC family currently comprises four members (HERC3–6) involved in the
regulation of various physiological activities. Little is known about the role of HERCs in IFN …
regulation of various physiological activities. Little is known about the role of HERCs in IFN …
Pulmonary mesenchymal stem cells in mild cases of COVID-19 are dedicated to proliferation; in severe cases, they control inflammation, make cell dispersion, and …
A Henriques-Pons, DG Beghini, VS Silva… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in virtually all
tissues; they have potent self-renewal capacity and differentiate into multiple cell types. For …
tissues; they have potent self-renewal capacity and differentiate into multiple cell types. For …