The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …

The mitochondrion is a double membrane structured organelle involved in a variety of
regulatory functions such as calcium signaling, production of adenosine triphosphate …

A better understanding of the secondary injury mechanisms that occur after traumatic spinal
cord injury (SCI) is essential for the development of novel neuroprotective strategies linked …

Neurodegeneration is an age-dependent progressive phenomenon with no defined cause.
Aging is the main risk factor for neurodegenerative diseases. During aging, activated …

Abstract Ischemia-reperfusion (I/R) injury is a common pathological mechanism in many
retinal diseases, which can lead to cell death via mitochondrial dysfunction. Voltage …

Mitochondrial dysfunction involving mitochondria-associated ER membrane (MAM)
dysregulation is implicated in the pathogenesis of late-onset neurodegenerative diseases …