Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …

Interest in the tumour suppressor p53 has generated much information regarding the
complexity of its function and regulation in carcinogenesis. However, gaps still exist in our …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …

Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …