Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular
mechanisms are still not fully understood. Here, we show that upregulated DDX39B …

Background Heat shock protein 90 (HSP90) functions as a well-known onco-protein to
regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote
mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in …

Aberrant regulation of ubiquitination often leads to metabolic reprogramming in tumor cells.
However, the underlying mechanisms are not fully understood. Here we demonstrate that …

The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13. 3,
encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase …

Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to
the development of OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound …