Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Immune determinants of COVID-19 disease presentation and severity

P Brodin - Nature medicine, 2021 - nature.com
Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of
previously healthy individuals, but can cause life-threatening disease or persistent …

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

H Peckham, NM de Gruijter, C Raine… - Nature …, 2020 - nature.com
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

COVID-19 and sex differences: mechanisms and biomarkers

T Haitao, JV Vermunt, J Abeykoon, R Ghamrawi… - Mayo Clinic …, 2020 - Elsevier
Men are consistently overrepresented in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection, and coronavirus disease 2019 (COVID-19) severe outcomes …

Systemic lupus erythematosus in children and young people

A Charras, E Smith, CM Hedrich - Current rheumatology reports, 2021 - Springer
Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

[HTML][HTML] Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome

D Buonsenso, M Piazza, AL Boner… - Allergy and Asthma …, 2022 - ncbi.nlm.nih.gov
Background: Long COVID (coronavirus disease 2019) syndrome includes a group of
patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS …

Mechanisms and consequences of sex differences in immune responses

SE Dunn, WA Perry, SL Klein - Nature Reviews Nephrology, 2024 - nature.com
Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

Single-cell RNA sequencing reveals the heterogeneity of tumor-associated macrophage in non-small cell lung cancer and differences between sexes

Q Yang, H Zhang, T Wei, A Lin, Y Sun, P Luo… - Frontiers in …, 2021 - frontiersin.org
Non-Small Cell Lung Cancer (NSCLC) is a disease with high morbidity and mortality, which
has sex-related differences in prognosis and immunotherapy efficacy. However, the …