Background.—Under the auspices of the College of American Pathologists, a
multidisciplinary group of clinicians, pathologists, and statisticians considered prognostic …

For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of
embryonic development and direct the coordinated organogenesis, correct spatial …

Multidisciplinary in scope and fully up to date with the latest advances in medical oncology
and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant …

The production of metastasis appears to involve a number of different proteases including
the urokinase form of plasminogen activator, cathepsin B, cathepsin D and various …

It is the ability to invade and metastasize that ultimately determines the prognosis in cancer.
Comprising one of the key groups of molecules involved in invasion and metastasis are …

BACKGROUND Fatty acid synthase (FAS) is a molecule found in tumor cells from breast
carcinomas of patients whose prognosis is very poor. Recently, this molecule has been …

Lysosomal cysteine proteinases, the cathepsins (Cats) belong to the papain family of
proteinases, sharing a similar protein structure and mechanism of action. Subtle structural …

Evidence has accumulated that invasion and metastasis in solid tumors require the action of
tumor-associated proteases, which promote the dissolution of the surrounding tumor matrix …

Action of purified human cathepsin B on recombinant single-chain urokinase-type
plasminogen activator (pro-uPA) generated enzymatically active two-chain uPA (HMW-uPA) …