Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many
patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 …

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer
treatment but are associated with myocarditis. Here, we report that tumor-bearing mice …

Abstract Purpose of Review Arrhythmogenic cardiomyopathy (ACM) is a genetic disease
characterized by life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in …

Arrhythmogenic cardiomyopathy (ACM) is a life-threatening cardiac disease caused by
mutations in genes predominantly encoding for desmosomal proteins that lead to alterations …

Aims Arrhythmogenic cardiomyopathy (AC) is one of the most common inherited
cardiomyopathies, characterized by progressive fibro-fatty replacement in the myocardium …