The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis,
and rheumatoid arthritis is now well established. This had led to the emergence of a modern …

The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …

Abstract Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-
mediated destruction of insulin-producing β-cells. Its incidence has increased during the …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the
general mechanisms whereby tryptophan catabolism affects T cell responses remain …

Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through
autoimmunity targeted at a diverse, yet limited, series of molecules that are expressed in the …

▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

This review considers the pathogenesis, scope, and treatment of autoimmune polyendocrine
syndromes. Although some of the component disorders such as thyroid autoimmunity and …