Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Atherosclerosis is a chronic inflammatory disease associated with cardiovascular
dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke …

Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized
by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a …

Objective—Cathepsin S (CatS) participates in atherogenesis through several putative
mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell …

This study tested the hypothesis that valsartan (Val) and melatonin (Mel)-assisted adipose-
derived mesenchymal stem cells (ADMSCs) preserved the residual renal function in chronic …

Background and aims Exposure to psychosocial stress is a risk factor for cardiovascular
disorders. Because the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist prevents …

Objectives Exposure to psychosocial stress is a risk factor for cardiovascular disease. Given
that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways …

The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths
worldwide each year. However, there are currently no effective drug therapies to prevent …

Abstract β-Elemene is a major bioactive sesquiterpenoids compound isolated from the
essential oils of Curcuma Wenyujin, a Chinese medicinal herb that treats tumor in clinics …