The chemistry and biology of guanidine natural products
RGS Berlinck, AF Bertonha, M Takaki… - Natural product …, 2017 - pubs.rsc.org
Covering: 2015 and 2016 The chemistry and biology of natural guanidines isolated from
microbial culture media, from marine invertebrates, as well as from terrestrial plants and …
microbial culture media, from marine invertebrates, as well as from terrestrial plants and …
Virus Management Using Metal–Organic Framework-Based Technologies
The eradication and isolation of viruses are two concurrent approaches to protect ourselves
from viral infections and diseases. The quite versatile porous materials called metal–organic …
from viral infections and diseases. The quite versatile porous materials called metal–organic …
Multifunctional ionic porous frameworks for CO 2 conversion and combating microbes
Porous organic frameworks (POFs) with a heteroatom rich ionic backbone have emerged as
advanced materials for catalysis, molecular separation, and antimicrobial applications. The …
advanced materials for catalysis, molecular separation, and antimicrobial applications. The …
The thiazole-5-carboxamide GPS491 inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing/accumulation
Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1,
5350150 (2-(2-(5-nitro-2-thienyl) vinyl) quinoline), led to the identification of the thiazole-5 …
5350150 (2-(2-(5-nitro-2-thienyl) vinyl) quinoline), led to the identification of the thiazole-5 …
Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency
C Schonhofer, J Yi, A Sciorillo… - Biochemical …, 2021 - Elsevier
While combination antiretroviral therapy (cART) durably suppresses HIV replication, virus
persists in CD4+ T-cells that harbor latent but spontaneously inducible and replication …
persists in CD4+ T-cells that harbor latent but spontaneously inducible and replication …
2-Trifluoromethylthiazole-5-carboxamides: analogues of a stilbene-based anti-HIV agent that impact HIV mRNA processing
M Zamiri, PK Cheung, MA Brockman… - ACS Medicinal …, 2021 - ACS Publications
The observation that stilbene 3 (5350150) blocks HIV replication through its impact on HIV
mRNA processing prompted a program to develop non-cytotoxic analogues that maintain its …
mRNA processing prompted a program to develop non-cytotoxic analogues that maintain its …
Impact of combinations of clinically observed HIV integrase mutations on phenotypic resistance to integrase strand transfer inhibitors (INSTIs): a molecular study
PK Cheung, A Shahid, W Dong, KJ Lepik… - Journal of …, 2022 - academic.oup.com
Background Routine HIV drug resistance genotyping identified an integrase sequence
harbouring T97A, E138K, G140S and Q148H, with high predicted resistance to all integrase …
harbouring T97A, E138K, G140S and Q148H, with high predicted resistance to all integrase …
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A
HIV-1 inhibitors that act by mechanisms distinct from existing antiretrovirals can provide
novel insights into viral replication and potentially inform development of new therapeutics …
novel insights into viral replication and potentially inform development of new therapeutics …
Phlorotannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products
MA Langarizadeh, A Abiri… - Biotechnology and …, 2021 - Wiley Online Library
The importance of new effective treatment methodologies for human immunodeficiency virus
(HIV) is undeniable for the medical society. Viral protein U (Vpu), one of the disparaged …
(HIV) is undeniable for the medical society. Viral protein U (Vpu), one of the disparaged …
Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction
Abstract Novel ethyl 2-(5-aryl-1 H-imidazol-1-yl)-acetates 17 and propionates 18, together
with their acetic acid 19 and acetohydrazide 20 derivatives, were designed and synthesized …
with their acetic acid 19 and acetohydrazide 20 derivatives, were designed and synthesized …