After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment
represents a transition between normal cognition and dementia. The frequency of cognitive …

All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

Alzheimer disease (AD) is usually accompanied by two prominent pathological features,
cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary …

The global population is expected to have about 131.5 million people living with Alzheimer's
disease (AD) and other dementias by 2050, posing a severe health crisis. Dementia is a …

Introduction Despite a large preclinical literature demonstrating neuroprotective effects of
estrogen, use of menopausal hormone therapy (HT) for Alzheimer's disease (AD) risk …

Objective Women have a higher lifetime risk of Alzheimer's disease (AD) than men. Among
cognitively normal (CN) older adults, women exhibit elevated tau positron emission …

Thyroid hormone (TH) regulates many functions including metabolism, cell differentiation,
and nervous system development. Alteration of thyroid hormone level in the body can lead …

Importance Postmenopausal females represent around 70% of all individuals with
Alzheimer disease. Previous literature shows elevated levels of tau in cognitively …

Background and Objectives To examine associations between indicators of estrogen
exposure from women's reproductive history and brain MRI biomarkers of Alzheimer disease …