Deregulation of ribosomal proteins in human cancers
W El Khoury, Z Nasr - Bioscience Reports, 2021 - portlandpress.com
The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …
LncRNA-encoded peptide: functions and predicting methods
Long non-coding RNA (lncRNA) was originally defined as the representative of the non-
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …
[HTML][HTML] m6A enhances the phase separation potential of mRNA
RJ Ries, S Zaccara, P Klein, A Olarerin-George… - Nature, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent modified nucleotide in mRNA,,
with around 25% of mRNAs containing at least one m6A. Methylation of mRNA to form m6A …
with around 25% of mRNAs containing at least one m6A. Methylation of mRNA to form m6A …
[HTML][HTML] Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
Abstract N 6-methyladenosine (m6A) is an abundant internal RNA modification in both
coding and non-coding RNAs, that is catalysed by the METTL3–METTL14 methyltransferase …
coding and non-coding RNAs, that is catalysed by the METTL3–METTL14 methyltransferase …
[HTML][HTML] The translational landscape of the human heart
Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs
JY Kang, Z Wen, D Pan, Y Zhang, Q Li, A Zhong, X Yu… - Science, 2022 - science.org
Postmeiotic spermatids use a unique strategy to coordinate gene expression with
morphological transformation, in which transcription and translation take place at separate …
morphological transformation, in which transcription and translation take place at separate …
Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia
J Paris, M Morgan, J Campos, GJ Spencer… - Cell stem cell, 2019 - cell.com
Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells
(HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self …
(HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self …
[HTML][HTML] Transcriptome-wide measurement of translation by ribosome profiling
NJ McGlincy, NT Ingolia - Methods, 2017 - Elsevier
Translation is one of the fundamental processes of life. It comprises the assembly of
polypeptides whose amino acid sequence corresponds to the codon sequence of an …
polypeptides whose amino acid sequence corresponds to the codon sequence of an …
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells
(SSCs) produce haploid spermatozoa. This highly specialized process is precisely …
(SSCs) produce haploid spermatozoa. This highly specialized process is precisely …
An RNA thermoswitch regulates daytime growth in Arabidopsis
Temperature is a major environmental cue affecting plant growth and development. Plants
often experience higher temperatures in the context of a 24 h day–night cycle, with …
often experience higher temperatures in the context of a 24 h day–night cycle, with …