Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …

Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular
rarefaction and development of vascular cognitive impairment and dementia (VCID) in the …

Sex is an important determinant of brain microvessels (MVs) function and susceptibility to
cerebrovascular and neurological diseases, but underlying mechanisms are unclear. Using …

Significance: Hypertension has major health consequences, which is associated with
endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) …

Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs
the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The …

Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the
mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with …

Sex differences in mitochondrial numbers and function are present in large cerebral arteries,
but it is unclear whether these differences extend to the microcirculation. We performed an …

Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …